Article
The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function.
BMC developmental biology - 27 Feb 2009
Yatsenko A S, Kucherenko M M, Pantoja M, Fischer K A, Madeoy J, Deng W-M, Schneider M, Baumgartner S, Akey J, Shcherbata H R, Ruohola-Baker H
Abstract excerpt
BACKGROUND: Dystroglycan (Dg) is a transmembrane protein that is a part of the Dystrophin Glycoprotein Complex (DGC) which connects the extracellular matrix to the actin cytoskeleton. The C-terminal end of Dg contains a number of putative SH3, SH2 and WW domain binding sites. The most C-terminal PPXY motif has been established as a binding site for Dystrophin (Dys) WW-domain. However, our previous studies...
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