Article
In vitro activity of 20 agents in different prognostic subgroups of chronic lymphocytic leukemia--rolipram and prednisolone active in cells from patients with poor prognosis.
European journal of haematology - 1 Jul 2009
Lindhagen Elin, Norberg Maria, Kanduri Meena, Tobin Gerard, Säisänen Laura, Aberg Magnus, Gustafsson Mats G, Sundström Christer, Rosenquist Richard, Aleskog Anna
Abstract excerpt
BACKGROUND: There is a need for development of new drugs for treatment of B-cell chronic lymphocytic leukemia (CLL), especially for poor-prognostic subgroups resistant to conventional therapy. OBJECTIVE: The in vitro antileukemic activity of 20 different anticancer agents was characterized in tumor cells from CLL, aiming at identifying agents active in poor-prognostic subgroups. DESIGN AND METHODS: In tumor cells...
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