Article
Characterization of functionally typical and atypical types of polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism - 1 May 2009
Hirshfeld-Cytron Jennifer, Barnes Randall B, Ehrmann David A, Caruso Anthony, Mortensen Monica M, Rosenfield Robert L
Abstract excerpt
CONTEXT: The typical polycystic ovary syndrome (PCOS) phenotype includes 17-hydroxyprogesterone (17OHP) hyperresponsiveness to GnRH agonist (GnRHag) testing. Functionally atypical PCOS lacks this feature. OBJECTIVE: The hypothesis was tested that the typical PCOS ovarian dysfunction results from intrinsically increased sensitivity to LH/human chorionic gonadotropin (hCG) due to a flaw in FSH action....
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