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Article

VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.

The Journal of biological chemistry - 1 May 2009

Gitcho Michael A, Strider Jeffrey, Carter Deborah, Taylor-Reinwald Lisa, Forman Mark S, Goate Alison M, Cairns Nigel J

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) with inclusion body myopathy and Paget disease of bone is a rare, autosomal dominant disorder caused by mutations in the VCP (valosin-containing protein) gene. The disease is characterized neuropathologically by frontal and temporal lobar atrophy, neuron loss and gliosis, and ubiquitin-positive inclusions (FTLD-U), which are distinct from those seen in other sporadic and...

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Source

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Identifiers

PMID: 19237541
DOI: 10.1074/jbc.M900992200
PMCID: PMC2673306

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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