Article
Effects of colistin on surface ultrastructure and nanomechanics of Pseudomonas aeruginosa cells.
Langmuir : the ACS journal of surfaces and colloids - 9 Apr 2009
Mortensen Ninell P, Fowlkes Jason D, Sullivan Claretta J, Allison David P, Larsen Niels B, Molin Søren, Doktycz Mitchel J
Abstract excerpt
Chronic lung infections in cystic fibrosis patients are primarily caused by Pseudomonas aeruginosa. Though difficult to counteract effectively, colistin, an antimicrobial peptide, is proving useful. However, the exact mechanism of action of colistin is not fully understood. In this study, atomic force microscopy (AFM) was used to evaluate, in a liquid environment, the changes in P. aeruginosa morphology and...
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