Article
Leptin, insulin, and obesity-related phenotypes: genetic influences on levels and longitudinal changes.
Obesity (Silver Spring, Md.) - 1 Jul 2009
Friedlander Yechiel, Meiner Vardiella, Sharon Nir, Siscovick David S, Miserez Andre R
Abstract excerpt
This study estimated the genetic and environmental determinants of plasma leptin and insulin levels and of obesity-related phenotypes. Included in this analysis were family members from 80 families living in kibbutz settlements, who participated in two examinations 8-10 years apart. We estimated that polygenes explained 30-50% of the adjusted leptin and insulin levels and 30-70% of the anthropometric phenotypes....
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