Article
Molecular characteristics of papillary thyroid carcinomas without BRAF mutation or RET/PTC rearrangement: relationship with clinico-pathological features.
Endocrine-related cancer - 1 Jun 2009
Durand Stéphanie, Ferraro-Peyret Carole, Joufre Mireille, Chave Annie, Borson-Chazot Françoise, Selmi-Ruby Samia, Rousset Bernard
Abstract excerpt
About 60-70% of papillary thyroid carcinomas (PTC) present a BRAF(T1799A) gene mutation or a rearrangement of RET gene (RET/PTC). In this study, we examined whether PTC without BRAF(T1799A) mutation and without RET/PTC rearrangement named PTC-ga(-) were distinguishable from PTC-ga(+) (with one or the other gene alteration) on the basis of gene expression characteristics. We analyzed the mutational state of 116...
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