Article
[Cloning and analysis of coding cDNA sequence of human lymphocyte Csk tyrosine kinase under normal conditions and in choroidal melanoma].
Izvestiia Akademii nauk. Seriia biologicheskaia - 1 Jan 2000
Baranova L A, Emel'ianova V P, Zhornik E V, Minov A M, Naumenko L V, Volotovskiĭ I D
Abstract excerpt
The main function of Csk tyrosine kinases is phosphorylation of the C-terminal part of Srk tyrosine kinases as a mechanism of their downregulation. A decrease in the expression of csk gene results in the enhancement of Srk tyrosine kinase activity. In this study, cDNA containing the full coding sequence of the human leukocyte Csk tyrosine kinase gene has been cloned. The protein encoded by a a 1624-bp cDNA...
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