Beta-thalassemia, HB S-beta-thalassemia and sickle cell anemia among Tunisians.

doi:10.3109/03630269109072481

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Article

Beta-thalassemia, HB S-beta-thalassemia and sickle cell anemia among Tunisians.

Hemoglobin - 1 Jan 1991

Fattoum S, Guemira F, Oner C, Oner R, Li H W, Kutlar F, Huisman T H

Abstract excerpt

We analyzed the mutations present in 19 patients with beta-thalassemia major, in 11 patients with Hb S-beta-thalassemia, and the beta S haplotypes of 34 patients with sickle cell anemia. The study included 84 relatives. Dot-blot analysis of amplified DNA with various specific oligonucleotide probes identified 11 different known beta-thalassemia mutations and frameshifts; a new frameshift at codons 25/26 (+T) was...

Topics

Adolescent
Adult
Alleles
Anemia, Sickle Cell
Child, Preschool
Codon
Consanguinity
DNA Mutational Analysis
Female
Frameshift Mutation
Globins
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Incidence

Infant

Male

Middle Aged

Oligonucleotide Probes

Source

Open in PubMed

Identifiers

PMID: 1917531
DOI: 10.3109/03630269109072481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1917531-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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