Article
Covariate adjusted correlation analysis with application to FMR1 premutation female carrier data.
Biometrics - 1 Sept 2009
Sentürk Damla, Nguyen Danh V, Tassone Flora, Hagerman Randi J, Carroll Raymond J, Hagerman Paul J
Abstract excerpt
Motivated by molecular data on female premutation carriers of the fragile X mental retardation 1 (FMR1) gene, we present a new method of covariate adjusted correlation analysis to examine the association of messenger RNA (mRNA) and number of CGG repeat expansion in the FMR1 gene. The association between the molecular variables in female carriers needs to adjust for activation ratio (ActRatio), a measure which...
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