Article
[A comparative study of the role of the yadA, invA, and psaA genes in the pathogenicity of Yersinia pseudotuberculosis].
Molekuliarnaia genetika, mikrobiologiia i virusologiia - 1 Jan 2008
Karataev G I, Markov A R, Siniashina L N, Miller G G, Klitsunova N V, Titova I V, Semin E G, Goncharova N I, Pokrovskaia M S, Amelina I P, Amoako K, Smirnov G B
Abstract excerpt
The roles of yadA, invA, and psaA genes introduced into the genetic background of the Y. pseudotuberculosis strain possessing the large p VM82 plasmid in virulence and invasion capacity were studied. Isogenic single mutants as well as double and multiple mutants of these genes were constructed and used. LD50 was used as a measure of virulence and the estimation of the ability to invade mammalian cells and the...
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