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Strategies for the Discovery of New Natural Products by Genome Mining

22 Jan 2009

Abstract excerpt

Abstract New drugs from silent gene clusters : Analysis of genome sequence data has identified numerous “cryptic” gene clusters encoding novel natural product biosynthetic assembly lines; this suggests that many new bioactive metabolites remain to be discovered, even in extensively investigated organisms. Several related and complementary strategies for identifying the products of these clusters have emerged...

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PMID: 19165837
DOI: 10.1002/cbic.200800389

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