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Alternative lengthening of telomeres frequently occurs in mismatch repair system‐deficient gastric carcinoma

19 Dec 2008

Abstract excerpt

Maintenance of telomeric ends by the telomerase ribonucleoprotein complex or the telomerase-independent alternative lengthening of telomeres is necessary for the immortalization of human cells. The significance of alternative lengthening of telomeres has been suggested in DNA mismatch repair system-deficient cells; however, much remains unknown in human malignancies. In this study, we investigated the telomere...

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PMID: 19154407
DOI: 10.1111/j.1349-7006.2008.01063.x

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