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Article

Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men.

Asian journal of andrology - 1 Jan 2000

Ounis Leyla, Zoghmar Abdelali, Coutton Charles, Rouabah Leila, Hachemi Maroua, Martinez Delphine, Martinez Guillaume, Bellil Ines, Khelifi Douadi, Arnoult Christophe, Fauré Julien, Benbouhedja Sebti, Rouabah Abdelkader, Ray Pierre F

Abstract excerpt

Klinefelter syndrome and Y-chromosomal microdeletion analyses were once the only two genetic tests offered to infertile men. Analyses of aurora kinase C (AURKC) and DPY19L2 are now recommended for patients presenting macrozoospermia and globozoospermia, respectively, two rare forms of teratozoospermia particularly frequent among North African men. We carried out genetic analyses on Algerian patients, to evaluate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25219909
DOI: 10.4103/1008-682X.136441
PMCID: PMC4291881

Genes

AURKC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men.PMID 25219909Read ↗

Two frequent loss-of-function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia.Semantic proximity Read ↗

Identification of a new recurrent aurora kinase C mutation in both European and African men with macrozoospermia.Semantic proximity Read ↗

Diagnostic genetic screening for assisted reproductive technologies patients with macrozoospermiaSemantic proximity Read ↗

Whole-exome sequencing identified a novel mutation of AURKC in a Chinese family with macrozoospermiaSemantic proximity Read ↗

Compound heterozygosity for novel AURKC mutations in an infertile man with macrozoospermia.Semantic proximity Read ↗

A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis.Semantic proximity Read ↗

The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population.Semantic proximity Read ↗

Successful intracytoplasmic sperm injection in a macrozoospermia case with novel compound heterozygous aurora kinase C (AURKC) mutations.Semantic proximity Read ↗

[Function of aurora kinase C (AURKC) in human reproduction].Semantic proximity Read ↗

Genetic aspects of monomorphic teratozoospermia: a review.Semantic proximity Read ↗

Teratozoospermia: spotlight on the main genetic actors in the human.Semantic proximity Read ↗

Comprehensive investigation in patients affected by sperm macrocephaly and globozoospermiaSemantic proximity Read ↗

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