Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells

Abstract excerpt

Key points Inadequate nutrient supply during fetal life results in intrauterine growth restriction (IUGR), which may lead to obesity, diabetes, and cardiovascular disease later in life. A decreased placental amino acid transporter activity has been implicated in the pathophysiology of IUGR; however, the mechanisms regulating placental amino acid transporters in the human are largely unknown. We show that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Birth, Development, and Health
• Share to Epigenetics and DNA Methylation
• Share to Pregnancy and preeclampsia studies