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Article

Rare Germline Mutations in Cyclin-Dependent Kinase Inhibitor Genes in Multiple Endocrine Neoplasia Type 1 and Related States

13 Jan 2009

Abstract excerpt

CONTEXT: Germline mutation in the MEN1 gene is the usual cause of multiple endocrine neoplasia type 1 (MEN1). However, the prevalence of identifiable germline MEN1 mutations in familial MEN1 cases is only 70%. Some cases may have a germline mutation in another gene such as the p27 cyclin-dependent kinase inhibitor (CDKI). OBJECTIVE: The aim of the study was to investigate cases of MEN1 or related states for...

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Identifiers

PMID: 19141585
DOI: 10.1210/jc.2008-2083

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