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Article

Genetic dissection of hyperthermia-induced neural tube defects in mice.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2003

Lundberg Yunxia Wang, Wing Michael J, Xiong Wanfen, Zhao Jian, Finnell Richard H

Abstract excerpt

BACKGROUND: Maternal hyperthermia has been shown to induce neural tube defects (NTD) in humans and in experimental animal systems. We report the first genetic dissection of maternal hyperthermia-induced NTD in mice. METHODS: After maternal exposure on E8.5 to 43 degrees C water bath for 10 min, we observed exencephaly frequencies among E15.5-17.5 fetuses from the following crosses and backcrosses,...

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Identifiers

PMID: 12962284
DOI: 10.1002/bdra.10044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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