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Article

Visual, base-specific detection of nucleic acid hybridization using polymerization-based amplification.

Analytical biochemistry - 15 Mar 2009

Hansen Ryan R, Johnson Leah M, Bowman Christopher N

Abstract excerpt

Polymerization-based signal amplification offers sensitive visualization of biotinylated biomolecules functionalized to glass microarrays in a manner suitable for point-of-care use. Here we report using this method for visual detection of multiplexed nucleic acid hybridizations from complex media and develop an application toward point mutation detection and single nucleotide polymorphism (SNP) typing. Primer...

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Identifiers

PMID: 19135969
DOI: 10.1016/j.ab.2008.12.009

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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