Article
Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema.
Allergy - 1 Feb 2009
Liedén A, Ekelund E, Kuo I-C, Kockum I, Huang C-H, Mallbris L, Lee S P, Seng L K, Chin G Y, Wahlgren C-F, Palmer C N A, Björkstén B, Ståhle M, Nordenskjöld M, Nordensköld M, Bradley M, Chua K Y, D'Amato M
Abstract excerpt
BACKGROUND: Eczema is a common chronic inflammatory skin disorder which shows strong genetic predisposition. To identify new potential molecular determinants of the disease pathogenesis, we performed a gene expression study in an eczema mouse model. This analysis identified a marked down regulation of the cornulin gene (CRNN), a member of the epidermal differentiation complex, in the eczema-like skin. We then...
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