Article
Apolipoprotein H promoter polymorphisms in relation to lupus and lupus-related phenotypes.
The Journal of rheumatology - 1 Feb 2009
Suresh Sangita, Demirci F Yesim K, Jacobs Erin, Kao Amy H, Rhew Elisa Y, Sanghera Dharambir K, Selzer Faith, Sutton-Tyrrell Kim, McPherson David, Bontempo Franklin A, Kammerer Candace M, Ramsey-Goldman Rosalind, Manzi Susan, Kamboh M Ilyas
Abstract excerpt
OBJECTIVE: Sequence variation in gene promoters is often associated with disease risk. We tested the hypothesis that common promoter variation in the APOH gene (encoding for ss(2)-glycoprotein I) is associated with systemic lupus erythematosus (SLE) risk and SLE-related clinical phenotypes in a Caucasian cohort. METHODS: We used a case-control design and genotyped 345 women with SLE and 454 healthy control women...
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