An evaluation of single nucleotide polymorphisms in the human heat shock protein 90 kDa α and β isoforms.

doi:10.2133/dmpk.dmpk-11-sc-114

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

An evaluation of single nucleotide polymorphisms in the human heat shock protein 90 kDa α and β isoforms.

Drug metabolism and pharmacokinetics - 1 Jan 2012

Urban Jonathan D, Budinsky Robert A, Rowlands J Craig

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in genes coding for proteins that maintain the cytosolic aryl hydrocarbon receptor (AHR) complex may affect individual susceptibility to dioxin-like compound (DLC)-induced toxicity. The cytosolic 90 kDa heat shock proteins (HSP90s) are ubiquitous chaperone proteins that bind to and stabilize numerous client proteins, including non-ligand-bound AHR. The objective of this...

Topics

Base Sequence
Cell Line, Transformed
HSP90 Heat-Shock Proteins
Humans
Molecular Sequence Data
Polymorphism, Single Nucleotide
Protein Isoforms

Source

Open in PubMed

Identifiers

PMID: 22185817
DOI: 10.2133/dmpk.dmpk-11-sc-114

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics