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Article

An evaluation of single nucleotide polymorphisms in the human heat shock protein 90 kDa α and β isoforms.

Drug metabolism and pharmacokinetics - 1 Jan 2012

Urban Jonathan D, Budinsky Robert A, Rowlands J Craig

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in genes coding for proteins that maintain the cytosolic aryl hydrocarbon receptor (AHR) complex may affect individual susceptibility to dioxin-like compound (DLC)-induced toxicity. The cytosolic 90 kDa heat shock proteins (HSP90s) are ubiquitous chaperone proteins that bind to and stabilize numerous client proteins, including non-ligand-bound AHR. The objective of this...

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Identifiers

PMID: 22185817
DOI: 10.2133/dmpk.dmpk-11-sc-114

Genes

AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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