Article
Gnotobiotic piglet infection model for evaluating the safe use of antibiotics against Escherichia coli O157:H7 infection.
The Journal of infectious diseases - 15 Feb 2009
Zhang Quanshun, Donohue-Rolfe Arthur, Krautz-Peterson Greice, Sevo Milica, Parry Nicola, Abeijon Claudia, Tzipori Saul
Abstract excerpt
BACKGROUND: Shiga toxin (Stx)-producing Escherichia coli (STEC), especially O157:H7, cause bloody diarrhea, and in 3%-15% of individuals the infection leads to hemolytic uremic syndrome (HUS) or other complications. Use of antibiotics to treat STEC infections is controversial. Here, we describe the use of piglets to evaluate the efficacy and mechanism of action of antibiotics in these infections. METHODS: The...
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