Article
Positive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virus.
PLoS pathogens - 1 Jan 2009
Botosso Viviane F, Zanotto Paolo M de A, Ueda Mirthes, Arruda Eurico, Gilio Alfredo E, Vieira Sandra E, Stewien Klaus E, Peret Teresa C T, Jamal Leda F, Pardini Maria I de M C, Pinho João R R, Massad Eduardo, Sant'anna Osvaldo A, Holmes Eddie C, Durigon Edison L
Abstract excerpt
Human respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple lineages of the HRSVA and HRSVB serotypes co-circulate within a single outbreak and display a strongly temporal pattern of genetic variation, with a replacement of dominant genotypes occurring...
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