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Microarray RNA Expression Analysis of Cerebral White Matter Lesions Reveals Changes in Multiple Functional Pathways

25 Dec 2008

Abstract excerpt

BACKGROUND AND PURPOSE: White matter lesions (WML) in brain aging are linked to dementia and depression. Ischemia contributes to their pathogenesis but other mechanisms may contribute. We used RNA microarray analysis with functional pathway grouping as an unbiased approach to investigate evidence for additional pathogenetic mechanisms. METHODS: WML were identified by MRI and pathology in brains donated to the...

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PMID: 19109541
DOI: 10.1161/strokeaha.108.529214

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