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Article

Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity.

Bioorganic & medicinal chemistry letters - 1 Feb 2009

Lyne Paul D, Aquila Brian, Cook Donald J, Dakin Les A, Ezhuthachan Jay, Ioannidis Stephanos, Pontz Timothy, Su Mei, Ye Qing, Zheng Xiaolan, Block Michael H, Cowen Scott, Deegan Tracy L, Lee John W, Scott David A, Custeau Dominique, Drew Lisa, Poondru Srinivasu, Shen Minhui, Wu Allan

Abstract excerpt

A series of amidoheteroaryl compounds were designed and synthesized as inhibitors of B-Raf kinase. Several compounds from the series show excellent potency in biochemical, phenotypic and mode of action cellular assays. Potent examples from the series have also demonstrated good plasma exposure fo...

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Identifiers

PMID: 19097792
DOI: 10.1016/j.bmcl.2008.10.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19097792-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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