Article
CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy.
PloS one - 1 Jan 2008
Horne Andrew W, Phillips John A, Kane Nicole, Lourenco Paula C, McDonald Sarah E, Williams Alistair R W, Simon Carlos, Dey Sudhansu K, Critchley Hilary O D
Abstract excerpt
BACKGROUND: Embryo retention in the Fallopian tube (FT) is thought to lead to ectopic pregnancy (EP), a considerable cause of morbidity. In mice, genetic/pharmacological silencing of cannabinoid receptor Cnr1, encoding CB1, causes retention of embryos in the oviduct. The role of the endocannabinoids in tubal implantation in humans is not known. METHODS AND FINDINGS: Timed FT biopsies (n = 18) were collected from...
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