Article
Potential of Advexin: a p53 gene-replacement therapy in Li-Fraumeni syndrome.
Future oncology (London, England) - 1 Dec 2008
Nemunaitis Jackie M, Nemunaitis John
Abstract excerpt
Li-Fraumeni syndrome is a rare autosomal dominant cancer predisposition syndrome. The majority of families fulfilling definition of Li-Fraumeni syndrome demonstrate inherited abnormalities involving the p53 gene. Cells with dysfunctional p53 are predisposed to the development of cancer phenotype....
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