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Article

Oxidant‐induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease

1 Dec 2008

Abstract excerpt

Considerable data support the hypothesis that mitochondrial abnormalities link gene defects and/or environmental insults to the neurodegenerative process. The interaction of oxidants with calcium and the mitochondrial enzymes of the tricarboxylic acid cycle are central to that relationship. Abnormalities that were discovered in brains or fibroblasts from patients with Alzheimer's disease (AD) have been modeled in...

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PMID: 19076444
DOI: 10.1196/annals.1427.038

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