Article
Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.
Antimicrobial agents and chemotherapy - 1 Mar 2009
Poirel Laurent, Rodriguez-Martinez José-Manuel, Plésiat Patrick, Nordmann Patrice
Abstract excerpt
Chromosomally encoded ss-lactamases from the Burkholderia cepacia complex species (formerly Pseudomonas cepacia) were characterized. Cloning and sequencing identified an Ambler class A ss-lactamase (PenB) from B. cenocepacia. It shares 82% amino acid identity with the PenA ss-lactamases previously identified from B. multivorans 249. Its expression was dependent upon a LysR-type regulatory protein. Its...
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