Article
Germline polymorphism of cancer susceptibility genes in gynecologic cancer.
Human cell - 1 Nov 2008
Ueda Masatsugu, Toji Eisaku, Nunobiki Osamu, Izuma Shinji, Okamoto Yoshiaki, Torii Kiyo, Noda Sadamu
Abstract excerpt
The multifactorial process of carcinogenesis involves mutations in oncogenes, or tumor suppressor genes, as well as the influence of environmental etiological factors. Common DNA polymorphisms in low penetrance genes have emerged as genetic factors that seem to modulate an individual's susceptibility to malignancy. Genetic studies, which lead to a true association, are expected to increase understanding of the...
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