Prediction of disease-associated single nucleotide polymorphisms using virtual genomes constructed from a public haplotype database.

doi:10.3414/me9129

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Article

Prediction of disease-associated single nucleotide polymorphisms using virtual genomes constructed from a public haplotype database.

Methods of information in medicine - 1 Jan 2008

Toyabe S, Miyashita A, Kitamura N, Kuwano R, Akazawa K

Abstract excerpt

OBJECTIVES: Simultaneous dealing of hundreds of thousands of single nucleotide polymorphisms (SNPs) in genome-wide association studies is laborious. The aim of our study is to develop a method to decrease the number of candidate SNPs prior to the genotyping of study subjects. METHODS: We created...

Topics

Alleles
Case-Control Studies
Data Collection
Genome, Human
Genotype
Haplotypes
Humans
Pilot Projects
Polymorphism, Single Nucleotide
Program Development
Time Factors
User-Computer Interface

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