Article
Prediction of disease-associated single nucleotide polymorphisms using virtual genomes constructed from a public haplotype database.
Methods of information in medicine - 1 Jan 2008
Toyabe S, Miyashita A, Kitamura N, Kuwano R, Akazawa K
Abstract excerpt
OBJECTIVES: Simultaneous dealing of hundreds of thousands of single nucleotide polymorphisms (SNPs) in genome-wide association studies is laborious. The aim of our study is to develop a method to decrease the number of candidate SNPs prior to the genotyping of study subjects. METHODS: We created virtual genotype data on case and control subjects from data of the International HapMap Project by using...
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