Article
Pregnancy-induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw-Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients.
British journal of haematology - 1 Mar 2009
Fujimura Yoshihiro, Matsumoto Masanori, Kokame Koichi, Isonishi Ayami, Soejima Kenji, Akiyama Nobu, Tomiyama Junji, Natori Kazuhiko, Kuranishi Yasunobu, Imamura Yutaka, Inoue Nobumasa, Higasa Satoshi, Seike Masako, Kozuka Teruhiko, Hara Masamichi, Wada Hideo, Murata Mitsuru, Ikeda Yasuo, Miyata Toshiyuki, George James N
Abstract excerpt
Upshaw-Schulman syndrome (USS) is a congenital thrombotic thrombocytopenic purpura (TTP) due to mutations in the gene that encodes for ADAMTS13 (ADAMTS13), but its clinical signs may be mild or absent during childhood. We have identified 37 patients with USS (24 females, 13 males) belonging to 32 families. The nine women from six families who were diagnosed during their first pregnancy are the focus of this...
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