Transfected trophoblast-derived human cells can express a single HLA class I allelic product.

doi:10.1111/j.1399-0039.1991.tb01850.x

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Article

Transfected trophoblast-derived human cells can express a single HLA class I allelic product.

Tissue antigens - 1 Feb 1991

Boucraut J, Hakem R, Gauthier A, Fauchet R, Le Bouteiller P

Abstract excerpt

The human trophoblast-derived JAR cell line, that does not express polymorphic HLA class I antigens even after IFN induction, can be stably transfected by genomic clones encoding the entire HLA-A2, -A3 and -B7 alpha-chain genes. The transfected genes were expressed at the cell surface in association with endogenous beta 2-microglobulin (shown by FCM analysis) as a single allelic product without reexpression of...

Topics

Alleles
Antigens, Neoplasm
Choriocarcinoma
Female
Gene Expression Regulation, Neoplastic
Genes, MHC Class I
HLA Antigens
Humans
Interferon-gamma
Methylation
Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

Stimulation, Chemical

Transcription Factors

Transfection

Trophoblasts

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 1905426
DOI: 10.1111/j.1399-0039.1991.tb01850.x

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1905426-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Transfected trophoblast-derived human cells can express a single HLA class I allelic product.PMID 1905426Read ↗

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A Class I Antigen, HLA-G, Expressed in Human TrophoblastsSemantic proximity Read ↗

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