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Article

IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes

1 May 1999

Abstract excerpt

HLA-G plays an essential role in feto-maternal tolerance by inhibiting lysis by maternal NK cells. The factors that allow tissue-specific activation of HLA-G gene expression in trophoblasts remain to be characterized. We investigated the potential effect of IL-10, a cytokine which is secreted in placenta, on HLA-G gene transcription in trophoblasts. Using Northern blot, RNase protection assay and RT-PCR analysis,...

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Identifiers

PMID: 10330285
DOI: 10.1093/intimm/11.5.803

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