Article
Absence of imprinting of HLA class Ia genes leads to co-expression of biparental alleles on term human trophoblast cells upon IFN-gamma induction.
Immunogenetics - 1 Mar 1998
Lenfant F, Fort M, Rodriguez A M, Campan A, Aguerre-Girr M, Sommer E, Abbal M, Ohayon E, Le Bouteiller P
Abstract excerpt
Human trophoblast cells have developed various efficient regulatory mechanisms to prevent cell surface expression of the classical HLA-A, -B, and (but not always) -C class I molecules. This allows them to escape maternal alloimmune attack during pregnancy. However, recent results have demonstrate...
Topics
- Alleles
- Female
- Gene Expression Regulation, Developmental
- Genes, Dominant
- Genes, MHC Class I
- Genomic Imprinting
- HLA Antigens
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens
- Humans
- Interferon-gamma
- Male
- Pregnancy
- Transcription, Genetic
- Trophoblasts