Loss of the oxidative stress regulator OxyR in Pseudomonas aeruginosa PAO1 impairs growth under iron-limited conditions.

Abstract excerpt

Pyoverdine is the main siderophore secreted by fluorescent pseudomonads to scavenge iron in the extracellular environment. Iron uptake, however, needs to be tightly regulated, because free iron stimulates the formation of highly toxic oxygen derivatives. In the opportunistic pathogen Pseudomonas aeruginosa, the transcriptional regulator OxyR plays a key role in the upregulation of defense mechanisms against...

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