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Article

Crosstalk between the Androgen Receptor and β-Catenin in Castrate-Resistant Prostate Cancer

1 Dec 2008

Abstract excerpt

The androgen-signaling pathway plays an important role in the development and hormonal progression of prostate cancer to the castrate-resistant stage (also called androgen-independent or hormone refractory). The Wnt pathway and beta-catenin contribute to prostate biology and pathology. Here application of Affymetrix GeneChip analysis revealed the genomic similarity of the LNCaP hollow fiber model to clinical...

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PMID: 19047173
DOI: 10.1158/0008-5472.can-08-1718

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