Article
Wfs1-deficient mice display impaired behavioural adaptation in stressful environment.
Behavioural brain research - 17 Mar 2009
Luuk Hendrik, Plaas Mario, Raud Sirli, Innos Jürgen, Sütt Silva, Lasner Helena, Abramov Urho, Kurrikoff Kaido, Kõks Sulev, Vasar Eero
Abstract excerpt
Wfs1-deficient mice were generated by disrupting the 8th exon of Wfs1 gene. Reproduction rates of homozygous Wfs1-deficient mice were slightly below the expected values, they displayed intolerance to glucose and overall lower body weight. The present behavioural study was performed in female Wfs1-deficient mice due to their milder metabolic disturbances. Non-fasting blood glucose levels did not differ between...
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