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Article

Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy.

Neurology - 20 Jan 2009

Johnson J N, Hofman N, Haglund C M, Cascino G D, Wilde A A M, Ackerman M J

Abstract excerpt

BACKGROUND: Long QT syndrome (LQTS) typically presents with syncope, seizures, or sudden death. Patients with LQTS have been misdiagnosed with a seizure disorder or epilepsy and treated with antiepileptic drug (AED) medication. The gene, KCNH2, responsible for type 2 LQTS (LQT2), was cloned originally from the hippocampus and encodes a potassium channel active in hippocampal astrocytes. We sought to test the...

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Source

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Identifiers

PMID: 19038855
DOI: 10.1212/01.wnl.0000335760.02995.ca
PMCID: PMC2677528

Genes

KCNH2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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