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Article

Association of IL-18 gene polymorphism (-137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A).

Clinical rheumatology - 1 Feb 2009

Hirankarn Nattiya, Tangwattanachuleeporn Marut, Wongpiyabovorn Jongkonnee, Wongchinsri Jeerapat, Avihingsanon Yingyos

Abstract excerpt

We analyzed the association between single nucleotide polymorphisms in IL-12 and IL-18 genes in disease susceptibility and severity of SLE in Thais. A weak association was observed between A allele of the IL-12 gene at the 3' untranslated region in SLE patients with proteinuria (OR = 1.89, 95% CI = 1.05-3.40, P = 0.02, Pc = 0.06). In addition, we found a significant association between C allele of IL-18 (-137)...

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PMID: 19031096
DOI: 10.1007/s10067-008-1036-4

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IFNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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