Article
Response of Porphyromonas gingivalis to heme limitation in continuous culture.
Journal of bacteriology - 1 Feb 2009
Dashper Stuart G, Ang Ching-Seng, Veith Paul D, Mitchell Helen L, Lo Alvin W H, Seers Christine A, Walsh Katrina A, Slakeski Nada, Chen Dina, Lissel J Patricia, Butler Catherine A, O'Brien-Simpson Neil M, Barr Ian G, Reynolds Eric C
Abstract excerpt
Porphyromonas gingivalis is an anaerobic, asaccharolytic, gram-negative bacterium that has essential requirements for both iron and protoporphyrin IX, which it preferentially obtains as heme. A combination of large-scale quantitative proteomic analysis using stable isotope labeling strategies and mass spectrometry, together with transcriptomic analysis using custom-made DNA microarrays, was used to identify...
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