Article
Doppel gene polymorphisms in Portuguese sheep breeds: insights on ram fertility.
Animal reproduction science - 1 Aug 2009
Pereira R M, Mesquita P, Batista M, Baptista M C, Barbas J P, Pimenta J, Santos I C, Marques M R, Vasques M I, Silva Pereira M, Santos Silva F, Oliveira Sousa M C, Fontes C M G, Horta A E M, Prates J A M, Marques C C
Abstract excerpt
Transgenic knockout of the gene encoding the prion-like protein Doppel leads to male infertility in mice. The precise role of Doppel in male fertility is still unclear, but sperm from Doppel-deficient mice appear to be unable to undergo the normal acrosome reaction necessary to penetrate the zona pellucida of the oocyte. The objective of this study was to characterize Doppel (Prnd) gene polymorphisms in eight...
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