Prognostic significance of the immunohistochemical expression of <i>O</i>⁶‐methylguanine‐DNA methyltransferase, P‐glycoprotein, and multidrug resistance protein‐1 in glioblastomas

Abstract excerpt

We studied the expression of O(6)-methylguanine-DNA methyltransferase (O(6)-MGMT), P-glycoprotein (Pgp), and multidrug resistance protein-1 (MRP-1) in 23 glioblastomas using RT-PCR, methylation-specific PCR, and immunohistochemistry, and analyzed their association with overall patient survival. Univariate analysis of collected data demonstrated that the expressions of O(6)-MGMT and MRP-1 detected by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug Transport and Resistance Mechanisms
• Share to Glioma Diagnosis and Treatment
• Share to Pancreatic and Hepatic Oncology Research