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Article

Analysis of N-acetylgalactosamine-4-sulfatase protein and kinetics in mucopolysaccharidosis type VI patients.

American journal of human genetics - 1 Apr 1991

Brooks D A, McCourt P A, Gibson G J, Ashton L J, Shutter M, Hopwood J J

Abstract excerpt

A sensitive and specific, monoclonal antibody-based immunoquantification assay has facilitated determination of the N-acetylgalactosamine-4-sulfatase (4-sulfatase) protein content in cultured fibroblasts from normal controls and mucopolysaccharidosis type VI (MPS VI) patients. The assay enabled the quantification of 4-sulfatase protein by using a panel of seven monoclonal antibodies and has shown that fibroblasts...

Topics

Antibodies, Monoclonal
Cells, Cultured
Chondro-4-Sulfatase
Dermatan Sulfate
Enzyme-Linked Immunosorbent Assay
Fibroblasts
Humans
Kinetics
Mucopolysaccharidoses
Phenotype
Reagent Kits, Diagnostic

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Identifiers

PMID: 1901688
PMCID: PMC1682943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1901688-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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