Article
A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells.
Nucleic acids research - 1 Dec 2008
Xu Mingang, McCarrey John R, Hecht Norman B
Abstract excerpt
Phosphoglycerate kinase 2 (PGK2) is a germ cell-specific protein whose mRNA is translationally regulated in the mammalian testis. Using RNA affinity chromatography with the 3'-untranslated region (UTR) of Pgk2 mRNA and adult testis extracts, several associated proteins including a novel isoform of the AU-rich element RNA-binding protein and KH-type splicing regulatory protein (KSRP) were identified. KSRP, a...
Topics
- 3' Untranslated Regions
- Animals
- Binding Sites
- Cytoplasm
- Genetic Variation
- HeLa Cells
- Humans
- Isoenzymes
- Male
- Meiosis
- Mice
- Nerve Tissue Proteins