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Article

The role of parental and grandparental epigenetic alterations in familial cancer risk.

Cancer research - 15 Nov 2008

Fleming Jessica L, Huang Tim H-M, Toland Amanda Ewart

Abstract excerpt

Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. These modifications take place throughout development with subsequent events occurring later in adulthood. Recent studies, however, suggest that some epigenetic alterations that influence cancer risk are inherited through the germline from parent to child and are observed in...

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PMID: 19010880
DOI: 10.1158/0008-5472.CAN-08-2184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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