Article
Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients.
Journal of the National Cancer Institute - 19 Nov 2008
van Zeeburg Hester J T, Snijders Peter J F, Wu Thijs, Gluckman Eliane, Soulier Jean, Surralles Jordi, Castella Maria, van der Wal Jacqueline E, Wennerberg Johan, Califano Joseph, Velleuer Eunike, Dietrich Ralf, Ebell Wolfram, Bloemena Elisabeth, Joenje Hans, Leemans C René, Brakenhoff Ruud H
Abstract excerpt
Fanconi anemia is a recessively inherited disease that is characterized by congenital abnormalities, bone marrow failure, and a predisposition to develop cancer, particularly squamous cell carcinomas (SCCs) in the head and neck and anogenital regions. Previous studies of Fanconi anemia SCCs, mainly from US patients, revealed the presence of high-risk human papillomavirus (HPV) DNA in 21 (84%) of 25 tumors...
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