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Could removing arsenic from tobacco smoke significantly reduce smoker risks of lung cancer?

Risk analysis : an official publication of the Society for Risk Analysis - 1 Jan 2009

Cox Louis Anthony

Abstract excerpt

If a specific biological mechanism could be determined by which a carcinogen increases lung cancer risk, how might this knowledge be used to improve risk assessment? To explore this issue, we assume (perhaps incorrectly) that arsenic in cigarette smoke increases lung cancer risk by hypermethylating the promoter region of gene p16INK4a, leading to a more rapid entry of altered (initiated) cells into a clonal...

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PMID: 19000069
DOI: 10.1111/j.1539-6924.2008.01145.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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