Article
Interleukin-10/interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family history.
American journal of respiratory and critical care medicine - 1 Feb 2009
Zhang Guicheng, Rowe Julie, Kusel Merci, Bosco Anthony, McKenna Kathy, de Klerk Nicholas, Sly Peter D, Holt Patrick G
Abstract excerpt
RATIONALE: Respiratory infections in early life are associated with risk for wheezing bronchiolitis, especially in children at high risk of atopy. The underlying mechanisms are unknown, but are suspected to involve imbalance(s) in host defense responses against pathogens stemming from functional immaturity of the immune system in this age group. OBJECTIVES: To assess the contribution of eosinophil-trophic IL-5,...
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