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Article

MALDI-TOF MS genotyping of polymorphisms related to 1-carbon metabolism using common and mass-modified terminators.

Clinical chemistry - 1 Jan 2009

Meyer Klaus, Fredriksen Ase, Ueland Per Magne

Abstract excerpt

BACKGROUND: Large cohort studies may provide sufficient power to disentangle the role of polymorphisms related to 1-carbon metabolism and chronic diseases, but they require fast, accurate, high-throughput genotyping techniques. MALDI-TOF mass spectrometry has been adapted to rapid fine mapping using various approaches for allele discrimination. We developed a genotyping method based on MALDI-TOF MS and compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 18988749
DOI: 10.1373/clinchem.2008.115378

Genes

BHMT
CBS
CTH
DHFR
FOLR1
MTHFD1
MTHFR
MTR
MTRR
NOS3
SHMT1
TCN2
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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